Rewire Your Mind and Reprogram Your Body | Brian J. Cole MD MBA

Imagine improving your physical performance without lifting a single weight—simply by rewiring your brain’s intent. That’s the promise of a groundbreaking Stanford study showing how belief and mental rehearsal can shape physical skills in real time, building new neural patterns that your body later executes—even if you haven’t physically practiced.

What Researchers Discovered

In the study published in Neuron, researchers used brain–machine interfaces (BMIs) to decode neural activity in monkeys. The animals were trained to move a cursor using only their thoughts. Next, the scientists introduced a change—a visuomotor rotation—so that neuronal commands previously mapped to moving the cursor straight up now moved it at a 45-degree angle instead. When the monkeys later repeated the task using their hands, they immediately adjusted their physical movements—even though they’d never practiced that adjustment with muscle movement. It’s as if the mind rewired the body first.

That adaptation demonstrates how beliefs, mental rehearsal, and intention can reorganize neural pathways—preparing the body in advance for new physical skills.

What It Means for Athletes and Coaches

This research gives scientific weight to sports principles we already know: mental imagery, confidence, and belief matter. But now we understand the neuroscience behind why they matter.

  1. Visualizing movement rewires your neurology: By vividly imagining movement and success, athletes prime the brain pathways needed for those motions. This can lead to faster learning when training physically begins.
  2. Belief changes performance outcomes: When athletes genuinely believe they can execute a skill, neural readiness primes the body for success. It’s not “just visualization”—it’s building a new motor plan inside the brain.
  3. Mental training may reduce physical wear: For athletes recovering from injury or during rest phases, mental rehearsal may maintain—or jumpstart—progress without physical stress.

How to Apply This in Practice

  • Incorporate guided mental rehearsal: Before practice, take time to deeply imagine the specific movements—seeing yourself perform with precision and confidence.
  • Add mindset coaching: Encourage athletes to shift internal narratives from “I have to get this” to “I can do this.” Neural priming can be just as powerful as reps.
  • Use imagery during recovery: Athletes sidelined by injury can still mentally rehearse their sport, helping preserve neural conditioning during downtime.

Final Thoughts

The Stanford study reveals that the brain can lead the body—rewiring itself in anticipation of physical action. For sports psychologists, coaches, and athletes, it’s a reminder that what happens in the mind truly shapes what the body can do. Training the mind isn’t optional—it’s essential.

References

Nathan Collins. Mental rehearsal prepares our minds for real‑world action. Stanford News (Feb 15, 2018). Study showed monkeys trained via brain–machine interface transferred neural learning to physical movement.

About the Author:

Dr. Brian Cole, MD, MBA - Orthopedic Sports Medicine Surgeon

Dr. Brian Cole is a board-certified orthopedic surgeon specializing in sports medicine and cartilage restoration at Midwest Orthopaedics at Rush. He serves as Managing Partner, Acting Department Chair, and Professor at Rush University Medical Center.

 

Credentials & Recognition

Dr. Cole earned his MD and MBA from the University of Chicago and completed his residency at the Hospital for Special Surgery. He was awarded the 2025 OREF Clinical Research Award and 2025 Golden GOAT Award for lifetime contributions to sports medicine. He's been listed in Best Doctors in America since 2004 and featured in Newsweek's 2025 Leading Doctors.

Clinical Expertise

Dr. Cole treats knee, shoulder, and elbow injuries using advanced cartilage restoration and orthobiologic techniques. He has published over 1,000 articles on orthopedic surgery and serves as team physician for the Chicago Bulls and Chicago White Sox.

Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. For diagnosis and treatment recommendations, please consult with Dr. Cole or another qualified orthopedic specialist at Midwest Orthopaedics at Rush.

Content authored by Dr. Brian Cole and verified against official sources.